BUB1B and Severe short stature: Furthermore, low levels of BubR1 in hypomorphic BubR1H/H mice result in the development of multiple progeroid features, including short lifespan, sarcopenia, reduced stress tolerance, cachectic dwarfism, lordokyphosis, cataracts, loss of subcutaneous fat, and impaired wound healing [1, 2, 39-41].