Analyzing the levels of AMBRA1 expression in PCa and BPH prostate tissues, we found significant differences: in 15 out of 26 PCa cases (58 %), the percentage of AMBRA1 positive cells was very high (more than 50 %) whereas all the positive BPH tissues (6 out of 12) displayed a lower positivity for AMBRA1, i.e., below 50 % (P < 0.001) (Table 4). Here, AMBRA1 is linked to posterior cortical atrophy.