AICDA and B-cell chronic lymphocytic leukemia: AID-mediated mutagenesis in B-1a IgVH may occasionally introduce mutations elsewhere in the genome that facilitate dysregulated growth and neoplastic transformation, e.g., B-chronic lymphocytic leukemia (B-CLL) (Stall et al., 1988; Kipps et al., 1992; Phillips and Raveche, 1992).