ALK gene rearrangements (ALK-R) have been detected in approximately 5–7% of all NSCLCs, with enrichment in a selected NSCLCs according to the specific clinicopathological features, such as ADC histotype, never/former light smoker (<10 packs/year), young and EGFR/KRAS wild-type patients [11]. This evidence concerns the gene EGFR and AIDS dementia complex.