Additionally, the knockdown ofCDH17 in GC cell lines (AGS and MKN-45) led to nuclear extravasation or cytoplasmicsequestration together with the potential degradation of β-catenin via the Wnt signalingpathway, which reduced the transactivation activity of lymphoid enhancer factor(LEF)/T-cell factor (TCF) transcription factors. This evidence concerns the gene HNF4A and gastric cancer.