However, based on a recent report thatindicated the existence of a trans-interaction between CDH17 and E-cadherin inenterocytes throughout intestinal epithelium development, we predict that CDH17interacts with the Wnt pathway via coordination with E-cadherin or E-cadherin-relatedpartners (29,30), although a previous study reported that targeting CDH17 inactivated theWnt/β-catenin signaling pathway in hepatocellular carcinoma (31). Here, CDH17 is linked to hepatocellular carcinoma.