Previously, we showed thatPOD-1 decreases SF-1 expression in human adrenocortical tumor cells by binding directlyto the SF-1 promoter, thereby inhibiting the activity of both SF-1 andits target StAR. Here, we showed that SF-1 was regulated by POD-1 innormal primary adrenocortical cells. The gene discussed is SF1; the disease is adrenal cortex neoplasm.