GPT and Cirrhosis: Multiple logistic regression analysis showed that pre-S deletions (OR, 8.253; 95% CI, 2.668–25.531; p<0.001) and 2 pre-S point mutations at codon 51 (OR, 13.917; 95% CI, 4.957–39.075; p<0.001), codon 167 (OR, 7.880; 95% CI, 2.717–22.852; p<0.001), ALT level (OR, 1.014; 95% CI, 1.002–1.025; p = 0.018) and cirrhosis (OR, 0.058; 95% CI, 0.022–0.157; p<0.001) were independent risk factors to the development of HCC (Table 2).