Obesity, diabetes, insulin, liver disease, increased triglycerides, endothelial stimulation (exercise, V2 receptor analogs, and surgery), fibrinogen, intravascular haemolysis, chronic inflammation, malignancy, hyperthyroidism, and renal disease also cause increase in factor VIII levels [13, 20]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.