The increase of proliferation in these cells occurs after induction of Cyclins D1 and E1, enhanced by the interaction with β-catenin [21]. In vivo and in vitro approaches have shown that LRH-1 overexpression promoted pancreatic cancer cell growth, proliferation, and angiogenesis by regulating Cyclins E1 and D1 [37]. The gene discussed is CCNE1; the disease is pancreatic neoplasm.