Subsequent analyses support their functional relevance to breast cancer risk that FGFR2 polymorphisms located in intron-2 alter the binding of two transcription factors, Oct-1/Runx2 and C/EBPb, resulting in an increase of FGFR2 gene expression both in cell lines and in breast tissue [28]. This evidence concerns the gene FGFR2 and breast carcinoma.