In order to investigate the regulatory effects of the IFN-α-sensitive CML cell-binding heptapeptide KLWVIPQ partially homologized with E3 ligase on the related protein levels and cell growth of CML cells, a novel recombinant expression plasmid expressing secretive heptapeptide KLWVIPQ was established in the present study. Here, IFNA1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.