With advanced molecular techniques, along with genes and proteins that have been identified as molecular markers for CCA, some of which have been practically used, more diverse and specific promising biomarkers in CCA have been established including the miRNA of miR-21, miR-200, miR-204, and enzymes such as GSTP, TFF, IDH, and mucins. This evidence concerns the gene IDH1 and cholangiocarcinoma.