ASPG and acute lymphoblastic leukemia: Clinical hypersensitivity reactions range in severity, from a localized rash or pain around the injection site to a systemic immune reaction, possibly resulting in anaphylaxis.108 The prevalence of asparaginase hypersensitivity in pediatric patients with ALL ranges from 3–45%.75,78,81,97,109,110 Although less clinical data exist in adult patients, hypersensitivity rates do not appear to differ with age.