ANGPTL2 and cancer: Angptl2 is expressed in the heart, adipose tissue, stomach, small intestine, colon, ovary, uterus, spleen, striated muscle, and, at lower levels, in other tissues and Angptl2 is secreted by different cell types such as adipocytes, endothelial cells, macrophages, keratinocytes and cancer cells [19, 20].