TP53 and carcinoma: Carcinogenic pathways may include (1) inflammation secondary to gallstones leading to p53 mutations and eventual carcinoma, (2) point mutation of Kras contributing to hyperplasia then carcinoma as seen in patients with an anomalous junction of pancreaticobiliary duct, and (3) neoplastic foci in gallbladder polyps secondary to Kras mutation [7].