WWOX and gallbladder cancer: Loss of heterozygosity (LOH) has been described in a number of tumour suppressor genes in gallbladder cancer including chromosomes 1p34–36 (p73), 3p (VHL, RAR-beta, RASSF1A, and FHIT), 5q21 (APC), 8p21–23 (PRLTS and FEZ1), 9p21 (p15, p16), 9q (DBCCR1), 13q14 (RB), 16q24 (WWOX and FRA16D), and 17p13 (p53) [29].