These findings are consistent with observations based on SIOP-UKCCSG-PNET3 (which included high-risk patients), where MYC/MYCN amplification were associated with LCA pathology and were prognostic in high-risk (i.e. when observed in tumors from patients with other high-risk disease features) but not standard-risk disease [7, 10]. The gene discussed is MYCN; the disease is Leber congenital amaurosis.