BIRC5 and rheumatoid arthritis: Importantly, in the pre-symptomatic stage of RA, survivin was associated with the pattern of regulatory cytokines (interleukin (IL)-12, IL-1, IL-9, granulocyte-macrophage colony-stimulating factor, and IL-2) controlling the formation of pathogenic T helper (Th) 1 and Th17 lymphocytes.