IGF1 and breast neoplasm: We furthermore observed that a series of oncogenic signaling genes such as EGF, IGF1, EGFR, MAPK and cell cycle genes CCNE1, CCND2, CDK1 were markedly upregulated by elevated expression of KLF4 in both MCF10A cells and MCF7 cells, which is consistent with the previous reported role for KLF4 in promoting cell growth in mammary gland and breast tumor cells42.