Importantly, both BP and syphilis were diagnosed at the usable molecular level with ELISA and IIFm for serum IgG antibodies to BP180 (Fig. 1c), and chemiluminescent microparticle immunoassay for serum antibodies to Treponema pallidum recombinant antigens (TpN15, TpN17, TpN47). This evidence concerns the gene COL17A1 and syphilis.