A study conducted by Keith T. Flaherty et al. in 2012 concluded that the combination of the BRAF inhibitor dabrafenib and the MEK inhibitor trametinib in patients with metastatic BRAF V600 melanoma, represents one strategy for delaying the emergence of this resistance mechanism (median duration of response for combination therapy 10.5 vs 5.6 months for dabrafenib monotherapy) [28]. The gene discussed is MAP2K7; the disease is melanoma.