Also in this case lentiviral transduction of PDX tumors with GFP-DTR did not alter tumor morphology and proliferative index (Ki67 expression; Supplementary Fig. 8) or the expression of differentiation and functional markers commonly employed for CRC classification (CDK20, CDX2 and b-catenin; Supplementary Fig. 9. Here, CDK20 is linked to neoplasm.