Despite the assumption that WMH are the result of SVD, the underlying pathogenesis is unclear and appears to be associated with a heterogeneous mixture of vascular and degenerative processes as determined by previous studies [24, 32, 33, 62], and our data that demonstrated increasing WMH severity with increasing cortical HPτ and Aβ pathology, SVD severity, and age. Here, MRS2 is linked to snowflake vitreoretinal degeneration.