RHBDF2 and Non-epidermolytic palmoplantar keratoderma: A diagnosis of tylosis with oesophageal cancer is made on the basis of a positive family history, characteristic clinical features, including focal palmar and plantar hyperkeratosis and oesophageal lesions, and mutations in RHBDF2. Oesophageal biopsies taken from individuals diagnosed with tylosis prior to the onset of oesophageal cancer do not have any specific distinctive features but tend to have prominent keratohyaline granules, inflammatory cell infiltrate and parakeratosis [14].