These results are in line with our previous study performed in overweight and obese patients, normotensive or with recently developed hypertension, never treated with antihypertensive drugs, showing that insulin and HOMAIR were not significantly different between normotensive and hypertensive subjects and were not associated to hypertension or to 24-h mean SBP or DBP levels [15]. The gene discussed is INS; the disease is hypertensive disorder.