Additionally, two sets of patients had tumors that were molecular identical twins, but these portfolios did not segregate by organ-based diagnosis: KRAS G12D and GNAS R201C without any other alterations were both found in one patient with each of lung adenocarcinoma and appendiceal cancer; CDK4 and MDM2 amplifications were found in one patient with lung adenocarcinoma and one with liposarcoma. This evidence concerns the gene MDM2 and liposarcoma.