EGFR and central nervous system cancer: Moreover, EGFRvIII CAR-engineered T cells exhibited a strong antitumor activity against glioma stem cells expressing mutant EGFRvIII, but not wild-type EGFR [57], while it is necessary to explore whether CAR-engineered CIK cells more efficiently killed stem-like cancer cells of various cancers, compared with CIK cells alone.