The authors also investigated the underlying mechanisms that suggested that during the normalization window, Endostar might increase the pericyte coverage of NPC tumor vessels via upregulation of a powerful endogenous anti-angiogenic and antitumor factor-Pigment epithelium-derived factor (PEDF) and downregulation of VEGF, thus inhibiting VEGF signaling that can be attributed to the local increase in oxygenation and decrease in tissue necrosis and edema. The gene discussed is VEGFA; the disease is nasopharyngeal carcinoma.