To determine whether genetic disruption of Flcn in mouse kidney distal tubule cells can lead to development of kidney neoplasm, we have previously generated distal tubule-collecting duct-specific knockout mice by breeding Flcnflox/flox mice to Ksp-Cre transgenic mice with expression of Cre-recombinase under the control of the kidney-specific cadherin promoter [31]. Here, FLCN is linked to kidney neoplasm.