TARDBP and amyotrophic lateral sclerosis: More recently, there was the discovery that the RNA/DNA binding protein TDP-43 (transactive response DNA binding protein 43 kDa) is a significant component of ubiquitin-positive intraneuronal inclusions in certain cases of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) (Neumann et al., 2006).