The rate of histologically aggressive meningiomas (grades II and III) was statistically higher in PGDStv-a;RCAS-PDGF-B;AdCre;Nf2flox2/flox2;Cdkn2ab−/− mice compared to AdCre;Nf2flox2/flox2;Cdkn2ab−/− mice (χ2, p = 0,002 and p = 0.03). This evidence concerns the gene PDGFB and meningioma.