We analyzed 36 NF2- meningiomas (defined as presenting either an identified NF2 mutation and 22q LOH, or 22q LOH with no NF2 protein expression on Western blot) and 18 NF2+ meningiomas (defined as presenting NF2 protein expression with no 22q LOH and no NF2 mutation). This evidence concerns the gene NF2 and meningioma.