To investigate the potential role of PDGF-B in meningioma initiation, we generated a cohort of 26 PGDStv-a;RCAS-PDGF-B mice and 19 PGDStv-a;RCAS-X control mice, injected with an empty RCAS vector (RCAS-X). This evidence concerns the gene PDGFB and meningioma.