PGDStv-a;RCAS-PDGF-B mice developed oligodendroglioma while in PGDStv-a; RCAS-PDGF-B;AdCre;Nf2flox2/flox2 mice and PGDStv-a;RCAS-PDGF-B;AdCre; Nf2flox2/flox2;Cdkn2ab−/− mice, all tumors grades were found, from WHO Grade II gliomas to WHO Grade IV glioblastomas. This evidence concerns the gene PDGFB and central nervous system cancer.