SLC6A3 and Alzheimer disease: We aimed to replicate the initial finding that the DAT promoter methylation state in blood is elevated in AD patients compared with HCs, and that the degree of DAT methylation covaries with alcohol craving.21, 22 In addition, we hypothesized that if DAT methylation affects its expression and if peripheral DAT methylation is reflective of DAT methylation in the brain, then elevated peripheral DAT methylation will be associated with stronger alcohol cue-induced blood oxygenation level dependent responses in mesolimbic brain areas (that is, NAc and amygdala), and could predict alcohol relapse.