CRH and brain inflammatory disease: We reported increased serum levels of the peptide neurotensin (NT) in children with ASDs.25 NT is a vasoactive peptide isolated from the brain26 and is implicated in immunity.27 We recently reported that serum levels of corticotropin-releasing hormone (CRH), secreted under stress, were also elevated together with NT in children with ASDs.28 CRH increased vascular permeability22 through a synergistic action with NT.29 Interactions among CRH, NT, microglia and MCs could contribute to brain inflammation.30, 31