In this view, the present observation of the synergistic expression of G-CSF, IL-8, CXCL1, and CXCL5 after co-treatment with IL-17A and polyI:C in NHBE cells indicates a significant role of airway epithelial cells in promoting excessive neutrophilic inflammation in viral-induced exacerbations of asthma. Here, CXCL5 is linked to asthma.