GPBAR1 and gastric neoplasm: To determine how TGR5 affected gastric tumor growth and progression, we transfected TGR5 overexpression plasmid to SGC7901 gastric cancer cells and examined the effect of TGR5 activation by its ligand, 23(S)-mCDCA and 3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethylisoxazole -4-carboxamide (GPBARA), on SGC7901 cell proliferation, migration and invasion.