Our previously reported GWAS in 3,444 CF patients led to identification of genome-wide significant single-nucleotide polymorphism (SNP) associations with lung disease severity in an intergenic region between EHF and APIP (chr11p13), as well as several additional suggestive loci (chr6p21.3 and chrXq22-q23)3. This evidence concerns the gene APIP and lung disorder.