Consensus guidelines to overcome confounding factors in TBI patients state that the GH/IGF-1 deficiency should be evaluated through a first line measurement of the basal anterior pituitary hormones, by dynamic endocrine testing such as the glucagon stimulation test, followed by the second line growth hormone releasing tests (GHRH), arginine test and GHRH + GHRP-6 and/or insulin tolerance test [86, 87]. Here, GH1 is linked to growth delay due to insulin-like growth factor type 1 deficiency.