IGF1 and hyperinsulinemic hypoglycemia, familial, 4: In this sense Kelly et al. [70] found 18% GH defect among patients with TBI, and Lieberman et al. [76] reported 15%, whereas Agha et al. [88] and Aimaretti et al. [89], respectively, indicated 18% and 37% of GH reduction and Abadi et al. [90] showed IGF-1 deficiency in 24% patients three months after injury.