Indeed, local high S100B concentration was detected only at the site of myocardial infarction and, finally, (iii) in humans, cardiac tissue contamination on S100B has been justified by a correlation between troponin I and S100B [23] although a hypoxia mediated effect could be reasonably the main explanation of the increase in circulating biomarkers' levels [3, 4]. This evidence concerns the gene S100B and myocardial infarction.