This concluded that “anti-VEGF pharmacotherapy, delivered by intravitreal injection, is reasonably safe and effective in the treatment of DME.” A statement by the Royal College of Ophthalmologists in their published diabetic retinopathy guidelines confirms that “anti-VEGF injections are considered the new gold standard of therapy for eyes with centre-involving macular oedema and reduced vision” [30, 31]. Here, VEGFA is linked to macular retinal edema.