Thus, Th1 cells, characterized by co-expression of IFNγ and T-bet; Th2 cells, characterized by co-expression of IL-4 and GATA-3; Th9 cells, characterized by co-expression of IL-9 and lack of IL-4; Th17 cells, characterized by co-expression of IL-17 and lack of IFNγ; nTregs, characterized by co-expression of CD25 and Foxp3 and aTregs, characterized by the lack of CD25 and Foxp3 expression can all express IL-10 both spontaneously and following TB-antigen stimulation in active and latent TB individuals. The gene discussed is GATA3; the disease is tuberculosis.