As two previously reported autoimmune myositis models, wt mice immunized with C protein [38, 53] and Syt7−/− mice [54, 55], did not develop myositis in our hand, we immunized mice of Syt7−/− background with C protein because impaired muscle membrane sealing due to Syt7 deficiency facilitates myositis induction [54, 56]. This evidence concerns the gene SYT7 and myositis disease.