When compared to the clinico-pathologic profiles of PCa in Jamaican men described by Shirley et al. [9] and Coard et al. [10] neither of whom differentiated between rural and urban dwelling in a clinical series of men diagnosed and treated in Kingston, median PSAs of 37 ng/ml and 30.7 ng/ml respectively were described which are higher than the overall median PSA of 19 ng/ml and the median rural PSA of 22.9 ng/ml in this study. The gene discussed is KLK3; the disease is posterior cortical atrophy.