In a 3-year research on male osteoporosis, SHBG positively correlated with C-telopeptide of type I collagen (CTx) and free deoxypyridinoline (D-Pyr) which were bone absorption markers after adjustment for age, BMI, and sex steroids in both health controls and postmenopausal osteoporosis (PMOP) patients. The gene discussed is SHBG; the disease is postmenopausal osteoporosis.