Therefore, in this study, we indicate that a crude polysaccharide isolated from enzymatic extracts of E. cava (CPs) contains the plentiful fucose and sulfated group contents and has an anticancer capacity against a colon cancer cell line, CT-26 cells by causing the apoptosis via the Bcl-2/Bax signaling pathway. Here, BAX is linked to malignant colon neoplasm.