A multiple logistic regression analysis was performed with CAD severity (Gensini score < or >40) as the dependent variable and the following as risk factors: age, family history of CAD, hypertension, smoking, hyperlipidemia, obesity, BMI, triglycerides, LDL-C, and insulin (Table 4). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.