On day 23 of tumor growth, the tumor volumes (mm3, mean ± SEM, n = 6) of the ME180-YAP group (952.5 ± 124.3) and the ME180-YAPS127A group (963.1 ± 232.6) were significantly larger than that of the ME180-MXIV group (236.8 ± 23.4) (P < 0.01) (Fig4A–D). This evidence concerns the gene YAP1 and neoplasm.