Treatment with the PI3K inhibitor LY294002 or the MEK inhibitor U0126 partially but significantly blocked TGF-α-stimulated YAP protein dephosphorylation, suggesting that the EGFR/PI3K and EGFR/MEK/ERK signaling pathways are involved in mediating the actions of TGF-α on the Hippo pathway in cervical cancer (Appendix Fig S11). This evidence concerns the gene TGFA and cervical carcinoma.