TLR4 and chronic kidney disease: To better understand the role of TLR4 on CKD progression, we first compared C3H/HeOuJ (TLR4 WT) mice with mice that have a missense point mutation in the Tlr4 gene, rendering the receptor nonfunctional (C3H/HeJ mice, henceforth called TLR4 mutant) (Hoshino et al.