In the Netherlands, an unique screening algorithm based on combined measurement of TSH, T4 and thyroxine binding globulin (TBG) results in a diagnosis of CCH in as many as 1 in 16 000 newborns, the majority of whom will have additional pituitary hormone deficits (van Tijn et al. 2005, Kempers et al. 2006). Here, SERPINA7 is linked to columnar cell hyperplasia of the breast.