GWAS studies for age at menopause has highlighted a key role for DNA repair pathways22, 40 and their putative relevance to PCOS is supported by the novel PCOS locus near to RAD50, a gene that is involved in DNA double-strand break repair and is mutated in the Nijmegen breakage syndrome-like disorder. The gene discussed is RAD50; the disease is Nijmegen breakage syndrome-like disorder.