However, apocynin treatment reversed these abnormities after sepsis development [14 days: one-way ANOVA; PFC (PV): F (3, 20) = 0.873, P = 0.471; hippocampus (PV): F (3, 20) = 14.661, P < 0.01]; [14 days: one-way ANOVA; PFC (gp91phox): F (3, 20) = 0.782, P = 0.518; hippocampus (gp91phox): F (3, 20) = 5.585, P = 0.01; Fig. 5c, e]; [30 days: one-way ANOVA; PFC (PV): F (3, 20) = 0.104, P = 0.957; hippocampus (PV): F (3, 20) = 0.019, P = 0.996]; [30 days: one-way ANOVA; PFC (gp91phox): F (3, 20) = 0.022, P = 0.996; hippocampus (gp91phox): F (3, 20) = 0.124, P = 0.945; Fig. 5d, f]. This evidence concerns the gene CYBB and Sepsis.