The gene had previously been identified as GW112, a gene highly expressed in colon cancers (Unigene ID#Hs.273321) and the protein was identified as pDP4 (PU.1 difference product 4), a glycoprotein secreted by mature murine granulocytes and induced at a late stage of maturation by the myeloid specific transcription factor PU.1 2. Here, OLFM4 is linked to malignant colon neoplasm.